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SLEEP FRAGMENTATION AND REM SLEEP IN MORBIDLY OBESE ADULTS WITHOUT SIGNIFICANT OBSTRUCTIVE SLEEP APNEA Pannain S, 1 Miller MA, 1 Leproult R, 1 Saaresranta T, 3 Alverdy J, 2 Prachand V, 2 Van Cauter E1 1 ; Medicine, The University of Chicago, Chicago, IL, USA, 2 ; Sleep Research Unit, University of Turku, Turku, Finland, 3 ; Department of Surgery, The University of Chicago, Chicago, IL, USA Introduction : Sleepiness and fatigue are frequent complaints of obese subjects even in the absence of obstructive sleep apnea OSA ; , yet little is known about sleep in morbid obesity. This study compares sleep in morbidly obese subjects without significant OSA as compared to age- and gender-matched lean controls. Methods : Thirty-five volunteers had an overnight laboratory polysomnography. The obese group n 17, 16 women ; aged 3510 yrs mean SD ; , had an average body mass index BMI ; of 539 kg m2 range: 40-80 kg m2 ; , and an AHI of 4.24.0 all 15 ; . The lean group n 16, 14 women ; aged 3411 years, had a BMI of 232 kg m2 range: 20-26 kg m2 ; and an AHI of 0.91.3 p 0.01 as compared to obese subjects ; . The subjects were not taking any medication known to affect sleep and or breathing. Results : In the morbidly obese, sleep latency to stage 1 tended to be shorter p 0.07 ; and wake after sleep onset longer WASO; 344 min versus 225 min ; after controlling for AHI and age p 0.05 ; . Morbidly obese subjects tended to have an increased number of microarousals p 0.07 ; . Two controls and two patients had a total number of microarousals 250. When these subjects where excluded from the analysis, the morbidly obese had a higher number of microarousals, independent of AHI 12018 versus 7419, p 0.005 by ANOVA ; . Sleep stage distribution was similar in both groups. In morbidly obese subjects, the amount of REM was inversely related to BMI r 0.511, p 0.036 ; . In contrast, there was no relationship between amount of REM and AHI or age. There was also no association between AHI and BMI. Conclusion : Morbidly obese subjects without significant SDB have more fragmented sleep than lean controls. High BMI appears to impact REM regulation. Support optional. At the National Institute of Drug Quality Control of Vietnam [NIDQC] using TLC and HPLC ; . Testing results indicate that two artesunate lots 030101 and 030801 ; contained no active ingredient. USP DQI notified relevant parties regional WHO, the Yunnan Quality Control Laboratory, colleagues in China at the Yunnan Institute of Parasitic Diseases who informed the Yunnan Health Bureau and subsequently, the regulatory body, and State Drug Administration ; so that the fake products can be removed from the drug outlets. Yunnan DRA is trying to investigate the main source s ; of these fake drugs. Zantac, Reductil, Stinox, Viagra, Cialis, flu drugs, unknown others Due to lax regulations in mainland China, ingredients for these drugs were imported to Taiwan for manufacture, packaging and sale. Up to 550, 000 pills were seized by the Criminal Investigation Bureau CIB ; . According to UK sources, some 100, 000 people in China died from illicit medicines in 2003. Counterfeit medicine ring busted. The China Post. 2005 Dec 9. : chinapost tw i latestdetail ?id 33348 Nigeria criticizes China over counterfeit threat. Daily International Pharma Alert. Feb 14, 2006; vol 3, no 31. fdanews WHO global taskforce to tackle counterfeit drugs. scripsnews , February 24, 2006, no. 3134, p. 16. Nine killed by fake Chinese Drug. May 22, 2005. : news.bbc go pr fr - asiapacific 5003548 m; and Harsh Penalties needed to discourage counterfeit production, says expert. May 18, 2006. : interfax.cn showfeature ?aid 1295 2&slug health and zyloprim.
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