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From the plant product xylan and contains linked beta-D-xylopyranoses attached to glycoside chains. Pentosan polysulfate has also been used in canine patients with osteoarthritis. In dogs the optimal dosage regimen is 3 mg kg q 57 days by SC injection. In horses, it has primarily been used in Australia, and the dose has been extrapolated from this canine data to 23 mg kg once weekly for 4 wk, repeated after 3 mo as required. Occasional local reactions to IM injection of this product have been observed. A number of oral medications are currently available that are claimed to be of benefit in the management of osteoarthritis. These primarily consist of chondroitin sulfate and or glucosamine sulfate hydrochloride. The efficacy of these products is not well established although there is increasing evidence of their effectiveness. Glucosamine may increase proteoglycan synthesis by chondrocytes as well as having anti-inflammatory properties. Chondroitin sulfate is also reported to have anti-inflammatory and chondroprotective benefits. There is currently debate regarding the efficacy of the two different glucosamine salts on the market glucosamine sulfate versus glucosamine hydrochloride ; but the salt form simply provides the delivery vehicle and the real issue of importance is that of product purity. Both glucosamine and low molecular weight chondroitin sulfate are absorbed after oral administration to horses, but the levels achieved in the target joint remain unclear. There also appears to be considerable individual variation in clinical results observed following this form of supplementation. When supplementation is used, a reputable product should be selected since and cisapride.

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